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Because of the dynamic nature of drug information, readers are advised that decisions regarding drug therapy must be based on the independent judgment of the clinician, changing information about a drug (eg, as reflected in the literature and manufacturer’s most current product information), and changing medical practices. The editors are not responsible for any inaccuracy of quotation or for any false or misleading implication that may arise due to the text or formulas as used or due to the quotation of revisions no longer official. The reader is advised that information on dosages of drugs should be verified. Actual dosing amount for any specific drug should be based on an in-depth evaluation of the individual patient’s therapy requirement and strong consideration given to such issues as contraindications, warnings, precautions, and adverse reactions, along with the interaction of other drugs. The manufacturers most current product information or other standard recognized references should always be consulted for such detailed information prior to drug use.